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COPD患者运动能力下降与住院相关

来源:慢性阻塞性肺病网 手术刀 2014-04-05 |
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摘要:
运动能力随时间下降,它是COPD患者健康状况与预后的一个重要决定因素。我们推测COPD患者运动能力下降与住院相关。
    运动能力随时间下降,它是COPD患者健康状况与预后的一个重要决定因素。我们推测COPD患者运动能力下降与住院相关。
 
    收集了342例稳定期COPD患者的临床及肺功能资料。测量基础和平均1.7±0.3 年后的6MWD,通过数据库管理中心获取住院的资料,运用直线回归方法分析运动能力变化模型。
 
     患者大多数为男性(92%),平均年龄67.9±8.6岁,支气管舒张后FEV1%为54±17%,基础6MWD为433±93米。随访期间,6MWD每年下降21.9±51米,153(占45%)例患者至少住院1次。仅因COPD原因住院的患者(占50%)中,每年6MWD明显下降的比例高于非呼吸道疾病原因住院的患者(53%比29%,P=0.040)。经调整混杂因素后,因至少一种原因住院的COPD患者的每年6MWD减少数高于没有住院的COPD患者(26米/年,95%可信区间,13-38米/年,P<0.001)。
 
    结论:COPD患者住院与运动能力下降明显相关。
 
    ABSTRACT  Exercise capacity declines with time and is an important determinant of health status andprognosis in patients with chronic obstructive pulmonary disease (COPD). We hypothesised that hospitaladmissions are associated with exercise capacity decline in these patients.
 
    Clinical and functional variables were collected for 342 clinically stable COPD patients. The 6-min walk distance (6MWD) was determined at baseline and after a mean¡SD of 1.7±0.3 years. Information on hospitalisations during follow-up was obtained from centralised administrative databases. Linear regression was used to model changes in exercise capacity.
 
    Patients were mostly male (92%), with mean ±SD age 67.9 ±8.6 years, post-bronchodilator forced expiratory volume in 1 s 54±17% predicted and baseline 6MWD 433 ±93 m. During follow-up, 6MWD decreased by 21.9±51.0 m .year-1 and 153 (45%) patients were hospitalised at least once. Among patients admitted only for COPD-related causes (50% of those ever admitted), the proportion presenting a clinically significant loss of 6MWD was higher than in patients admitted for only nonrespiratory conditions (53% versus 29%, p 5 0.040). After adjusting for confounders, annual 6MWD decline was greater (26 m . year-1,95% CI 13–38 m.year-1;p, 0.001) in patients with more than one all-cause hospitalisation per year, as compared with those with no hospitalisations. Hospitalisations are related to a greater decline in exercise capacity in COPD.
 
    文章原标题:Hospital admissions and exercise capacity decline in patients with COPD
 
    翻译:广州呼吸疾病研究所进修生李有霞    校正:郑则广教授

    想要了解更多相关专业知识,可浏览COPD门户网其他栏目!

    COPD门户网专栏,转载请标明出处,否则我们将会追究相关责任!
 
    相关链接:http://erj.ersjournals.com/content/43/4/1018.abstract.html?etoc
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